Open Access Case Report

Neuropsychiatric Syndrome in Choroideremia- A Rare Case Report

Pooja Misal, K. J. Nimitha, Porimita Chutia, Bhupendra Singh

International Neuropsychiatric Disease Journal, Page 1-4
DOI: 10.9734/indj/2022/v17i330200

Biomarkers of Alzheimer’s Disease (AD), and other neurodegenerative disorders are most exploring areas of clinical research in Geriatric Psychiatry. Presently neuroimaging, blood and CSF biomarkers are expensive and invasive to perform and are considered impractical for research purpose. The retinal presents a readily accessible tissue for monitoring the brain and could potentially be used in combination with or as a substitute for current AD and other neurodegenerative disease biomarkers. Data on retinal involvement in AD and neurodegenerative diseases have been controversial and inconsistent. So, we are reporting a case of Choroideremia with neuropsychiatric presentations and complications.

Open Access Original Research Article

Substance Use Disorders: Suicide and Self-Harm

Nahla Abdalla El-Morsy, Wessam Abd Al-Salam Ghareb, Gamal Taha Shama, Hossam El-Den Fathalla Alsawy

International Neuropsychiatric Disease Journal, Page 5-16
DOI: 10.9734/indj/2022/v17i330201

Aims: To specify the demographic and risk factors and type of the substance use disorders most common with suicidal behaviors and self-harm.

Study Design: Observational cross-sectional research.

Place and Duration of Study: Neuropsychiatry Department and Psychiatry, Neurology and neurosurgery center, Tanta University, Tanta, Egypt. The study was conducted for duration of 6 months from January 2019 to June 2019.

Methodology: This was enrolled 105 aged 18-50 years to assess the type of substance use disorders most common with suicidal behaviours and self-harm with any duration of illness. Subjects were divided into three equal groups: Group 1 included healthy control subjects with no addiction or psychiatric problems with no history suggestive of any health problems. Group 2 included patients with substance use disorders (addict group). Group 3 included psychiatric patients without substance use disorders. All patients were subjected to addiction severity index, Beck Depression Inventory-II, Hamilton Anxiety Rating Scale, Suicide probability scale, Barratt's impulsiveness scale, Self-Harm diagnosis scale and the positive and negative syndrome scale.

Results: There was a significantly different in the suicide categories among the cases with and without heroin intake (p=0.038). There was a significantly positive correlation among addiction severity index (ASI) and suicide score in the addiction group.

Conclusion: The incidence of anxiety and depression among individuals with substance use disorders is notably high, particularly at severe levels. We found also positive correlations between ASI and both suicide and self-harm scores in the addiction group. Depression and anxiety are frequently co-occurring in SUD patients.

Open Access Original Research Article

The Relationship between Sexual Dysfunctions and Depression in Premenopausal Women

Sara Salah Gaffer, Mohammad Abdel -Hakeem Seleem, Tarek Mohamed El Saba, Adel Abdel-Kareem Badawy

International Neuropsychiatric Disease Journal, Page 17-28
DOI: 10.9734/indj/2022/v17i330202

Aims: To evaluate SD in depressed married premenopausal women and to study mood in married women with primary sexual complain.

Study Design: Cross-sectional case control research.

Place and Duration of Study: Neuropsychiatry and Obstetrics and Gynecology departments at Tanta University Hospital. The study was conducted from April 2019 to the end of March 2020.

Methodology: This research involved 300 females. Subjects were allocated into three equal groups: group 1(females with major depressive disorders who met DSM-5 diagnostic criteria for Major depressive disorders and were drug naïve, group 2: females with primary sexual complain and/or disorders and group 3: normal healthy female did not have history of medical or psychiatric diseases. All cases were subjected to psychiatric interview by Arabic version of MINI, Arabic version of the female sexual index, Hamilton depression scale, Hamilton anxiety scale, quality of life (QOL) assessment and modified Fahmy and Sherbini scale for socioeconomic study.

Results: There was positive significant correlations between female sexual index and Hamilton depression and anxiety score (p <0.001, p=0.012 respectively). There were negative significant correlations between female sexual index and physical, Psychological, social domains and total score of modified Fahmy& Sherbiny scale (p=0.073, 0.039, 0.003, 0.009) respectively.

Conclusion: Severity of depression is correlated to severity of SD among female cases with major depressive disorder. QOL is affected significantly by depression and by presence of sexual complaints and/or disorders among women as high incidence of SD in women with probable depression and is linked with significantly worse QOL.

Open Access Original Research Article

Impact of Media Information in the Development of Novel Coronavirus Symptoms without the Disease: Nocebo Phenomenon

Vinanthi Hegde, N. Maheshbabu

International Neuropsychiatric Disease Journal, Page 29-37
DOI: 10.9734/indj/2022/v17i330205

Introduction: Nocebo works on the human belief system, believing that one can be infected with Covid can be understood by Nocebo.

Purpose:  The purpose of this research study was to see if the media showing coronavirus news can influence the development of covid-19 symptoms without the disease.

Methods: This study adopted a Qualitative Research Design. For this study, 9 participants were interviewed. Thematic analysis was used for coding the data.

Results: Results of the study indicated that fear threat was noticed throughout the pandemic which aroused anxiety in their life which also included, fear of infection, loss of loved ones, and inaccessibility to various things. This fear threat seems to be aroused from the constant media influence, and there are studies that support the results. 

Conclusion: The responses received from the participant indicated fear and anxiousness as major factor for developing the symptom.

Open Access Original Research Article

Neurological and Molecular Interactions of Phytoconstituents from Ricinus communis Root Extract- A Pharmacological and Computational Approach

M. Ganga Raju, V. Laxmi Prasanna, N. V. L. Suvarchala Reddy V, Ch. Sneha

International Neuropsychiatric Disease Journal, Page 38-46
DOI: 10.9734/indj/2022/v17i330206

The majority of epileptic patients takes numerous anticonvulsant medications and is still not treated successfully. These medications' produce chronic side effects and drug interactions, which restrict their use, constitute their major drawback. On the other hand, the fact that nature has given us plants that can be used as safe, all-natural treatments for illnesses with little side effects and minimal drug interactions has prompted researchers to focus on herbal remedies with anticonvulsant potential. The antiepileptic potential of the methanolic root extract of Ricinus communis was investigated in rodent models. Molecular docking studies using Schrodinger software was employed to study interactions with active site using PDB ID: 4MS4 (GABA agonist’s), 3WFG (glutamate antagonist), 5HCV (aspartate antagonist), 6J8G (sodium channel antagonist).  At 30 and 60 minutes, MERC effectively diminished various convulsive phases and provided strong defence against the MES model. In PTZ, MERC extract treated groups at a dose (200 mg/kg and 400 mg/kg) showed significant antiepileptic activity with percentage protection of 24% and 33% respectively against seizures and significantly (* = p<0.0001) increased the latency of the seizures. Molecular docking studies confirmed the GABA agonist’s effects, and the results revealed that quercetin. gallic acid, luteolic acid, gentixic acid, catechin, vanillic acid, ricinoilc acid and standard phenytoin, clonazepam has highest Glide scores against all the selected proteins which indicates a stronger receptor -ligand binding affinity. From in vivo and molecular docking results it is clear that methanolic root extract of Ricinus communis possessed significant antiepileptic activity.