Alzheimer's Repairs through the Role of Ketogenic Diet

Asma Saghir Khan *

Department of Home Economics, Mirpur University of Science and Technology (MUST), Azad Kashmir, Pakistan.

Nazish Zulfiqar

Department of Home Economics, Mirpur University of Science and Technology (MUST), Azad Kashmir, Pakistan.

Saliha Naseer

Department of Home Economics, Mirpur University of Science and Technology (MUST), Azad Kashmir, Pakistan.

Maryam Iftikhar

Department of Home Economics, Mirpur University of Science and Technology (MUST), Azad Kashmir, Pakistan.

*Author to whom correspondence should be addressed.


Abstract

Alzheimer's disorder is a devastating neurodegenerative ailment characterized by cognitive decline and reminiscence loss. As the look for powerful treatments continues, researchers have begun investigating the ability of the ketogenic food regimen to manage the signs and symptoms and development of the disease. The ketogenic eating regimen, a low-carbohydrate, high-fat dietary approach, promotes the manufacturing of ketones as an alternative strength supply for the brain. This article affords an overview of the position of the ketogenic weight-reduction plan in Alzheimer's disease and explores its capacity to repair and improve cognitive function in affected people. We discuss the mechanisms behind the ketogenic eating regimen's impact on mind electricity optimization, neuroprotection, insulin sensitivity, and metabolic health. While the ketogenic weight loss program shows promise, its limitations and issues also are discussed, consisting of challenges of adherence and long-term sustainability, ability dietary imbalances, and personal versions. In addition, research is needed to completely apprehend the therapeutic capability of the ketogenic food regimen in Alzheimer's disease and to decide its most fulfilling implementation as part of a comprehensive treatment approach. Alzheimer's disorder (AD) is a progressive neurodegenerative ailment characterized by cognitive decline, memory loss, and impaired everyday functioning. Currently, there's no treatment for the advert, and available remedy options are limited in their efficacy. However, rising proof shows that the ketogenic eating regimen (KD), an excessive-fats, low-carbohydrate dietary technique, may preserve the ability to manage advert or even sell neuronal repair. The metabolic disorder discovered in ad brains, inclusive of decreased glucose metabolism and impaired mitochondrial function, has led researchers to explore opportunities for electricity resources for brain cells. The KD induces a metabolic kingdom called ketosis, where the frame normally relies on ketone our bodies derived from fats as its most important fuel supply. Ketones provide a greater efficient electricity supply to the brain, bypassing the impaired glucose metabolism in advert patients. Research utilizing animal models and early human trials have validated that the KD exerts numerous useful outcomes on advert pathology. Those outcomes include lowering amyloid- beta (Aβ) plaque accumulation, mitigating neuroinflammation, improving mitochondrial characteristics, and promoting the manufacturing of mind-derived neurotrophic component (BDNF), a protein crucial for neuronal increase and survival. Additionally, the KD has been proven to enhance cognitive characteristics and memory in ad sufferers, although further research is wanted to set up its lengthy-term outcomes and protection.

Keywords: Alzheimer, inflammation, metabolic, Ketogenic Diet (KD), neurodegenerative disorder, cognitive, neuro inflammation, mechanisms, therapeutic


How to Cite

Khan , A. S., Zulfiqar , N., Naseer , S., & Iftikhar , M. (2023). Alzheimer’s Repairs through the Role of Ketogenic Diet. International Neuropsychiatric Disease Journal, 20(4), 1–9. https://doi.org/10.9734/indj/2023/v20i4405

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