Depression in Children with Epilepsy in a Teaching Hospital South/South Nigeria

Onyema Chidubem Abazie

Department of Mental Health/Psychiatry, University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, Rivers State, Nigeria.

Nonyenim Solomon Enyidah *

Department of Medicine, Faculty of Clinical Sciences, College of Health Sciences, Rivers State University, Port Harcourt, Nigeria.

Princewill Stanley

Department of Mental Health/Psychiatry, University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, Rivers State, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Background: Epilepsy affects over 50 million in the world with a life time prevalence of 7.6%. It is the commonest paediatric neurological disorder and about 80% of these children live in the developing countries. Depression is the most common psychiatric comorbid condition in children with epilepsy.

Objective: To investigate the prevalence of depression among children aged 9-18yr with epilepsy and evaluate factors associated with depression.

Methods: 380 children with epilepsy were interviewed using researcher designed questionnaire, the clinical version of DICA-IV in a 2nd stage design, after having been screened with CES-DC. The study was descriptive with psychometric evaluation. Data obtained were analysed using SPSS version 22.0. p-values<0.05 were statistically significant.

Results: Using the CES-DC with a cut- off point of 15 and above, 117 (30.8%) of the respondents had significant scores for depression. All the 117 who were interviewed with DICA-IV met the DSM-IV criteria for major depression with 40 (10.5%) of them currently very depressed requiring urgent attention. Sociodemographic factors of; sex revealed that males were more depressed than females p=0.000, OR: 0.86, Age showed 9-11yr with a strong association p=0.001, OR:1.91. Marital status- Divorced or separated parents showed a higher association p=0.01 OR:2.233. Children with longer duration of illness had a strong association p=0,025, OR:1.203 and the more frequent the seizures, the stronger the association p=0.001, OR:1,411.

Conclusion: There is relativelhjy high prevalence of depression in children with epilepsy in Port Harcourt. More health education is needed to provide a comprehensive care.

Keywords: Epilepsy, paediatrics, CES-DC, DICA-IV, sociodemographic factors


How to Cite

Abazie , Onyema Chidubem, Nonyenim Solomon Enyidah, and Princewill Stanley. 2023. “Depression in Children With Epilepsy in a Teaching Hospital South/South Nigeria”. International Neuropsychiatric Disease Journal 20 (3):1-8. https://doi.org/10.9734/indj/2023/v20i3395.

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References

Yang, Chunsong, Hao, Zilong, Mao Yifei, Xu, Qunfen et al. Depression in children with epilepsy from western China. A cross sectional survey. Medicine. 2020;99(24); 20647. DOI: 10.1097/MD 000.20647.

Aldenkamp AP, Arens J. The relative influence of EEG discharges, short non-convulsive seizures and type of epilepsy on cognitive function. Epilepsia. 2004;45: 54-63.

Gaustaut H. Dictionary of epilepsy, World Health Organization; Geneva. 1973;75.

Forsgren L. Incidence and prevalence In; Wallace SJ. Ferrell K. eds. Epilepsy in children, 2nd edn. London; Arnold. 2004;21-25.

osuntokun B.O, Adeuja A.O, Nottidge V.A et al. Prevalence of epilepsy in Nigerian Africans: A community- based study. Epilepsia. 1987;28:272-279.

Izuora G, Iloeje S. A review of neurological disorders seen at the paediatric neurology clinic at the university of Nigeria teaching hospital Enugu. Annals of Tropical Paediatric. 1999;2:185-190.

Asindi A. The pattern of neurological disabilities in children seen at the university of Calabar Teaching Hospital Nigeria. J. paediatr. 1986;13:127-31.

Johnstone MV, Seizure in children. In; Vaugh VC, Behrman RE, editors, Nelson Text book of paediatrics, 18th ed, Philadelphia: saunders. 2007;2457-75

Ekinci O, Titus JB, Rodopman AA, Berkem M, Trevathan E. Depression and anxiety in children adolescents with epilepsy; prevalence, risk factors and treatment. Journal of epilepsy and behaviour. 2009; 14:8-18.

Lambert M, Robertem M. Depression in epilepsy; aetiology, phenomenology and treatment. Epilepsia. 1999;40:21-44.

Faulstich ME, Carey MP, Ruggiero L, Enyart P, Gresham F. Assessment of depression in childhood and adolescents; An evaluation of the Centre for Epidemiological Studies Depression Scale for Children (CES-DC). The American Journal of Psychiatry; 1986.

Lenore Sawyer Radloff. The CES-D Scale. A self -report Depression scale for research in the general population. Applied Psychological Measurement. 1977;1(N03): 385-401.

Fendrich M, Weissman MM, and Warner V. screening for depressive disorder in children and adolescents. Validating the centre for epidemiologic studies depression scale for children. American Journal of Epidemiology. 1990;131;(3): 538-551.

Ogun OC, Gbiri CA, Akinola OA, Faseson A, Oye AO. Psychosocial correlates of depression in children and adolescents with epilepsy in Nigerian Neuropsychiatric Hospital. Journal of Clinical Case Repor. 2021;(2):210-217.

David Shaffer, Prudence Fisher, Christopher P, Lucas et al. NIMH Diagnostic Interview Schedule for children version IV (NIMH DISC-IV): for Depression, differences from previous versions, and reliability of some common diagnoses. Journal of American Academy of child and adolescence psychiatry. 2000;39(1):28-36.

Adewuya A, Ola B. Prevalence of risk factors for anxiety and depressive symptoms in Nigerian adolescents with epilepsy. Epilepsy behaviour. 2005;6:342 347.

Akinsulore A, Adewuya A. Psychosocial aspects of epilepsy in Nigeria: A review. Afr. Journal. 2010;13(5):351-356.

Gbiri CA, Akingbohungbe AD. Determinants of quality of life in Nigerian children and adolescents with epilepsy; A hospital- based study, DCID. 22:3.

Mariam Seyfhashemi, Parviz Bahadoran. Depression in children and adolescents with epilepsy; A 15yr research review of prevalence and demographic and seizure related correlates. Iranian Journal of Paediatrics. 2013;23(1):1-7.

Ettinger A, Weisbiot D, Nolan E. et al. Symptoms of depression and anxiety in paediatric epilepsy patients. Epilepsia, 1998;39(6):595-599.

Wolraich M, Felice ME, Droter D. The classification of child and adolescent mental diagnoses in primary care; Diagnostic and statistical manual for primary care (DSM-PC) child and adolescent version. Elk Grove Village. 111: American Academy of Paediatrics; 1996.

G. Stores. School children with at risk for learning and behaviour problems. Dev. Med. Child Neurol. 1978; 20:502-508.

Bilgic A. Velmaz S, Tira S, Deda G, Kilic EZ. Depression and anxiety severity in a group of children with epilepsy and related factors. Turk Psikiyatri Derg. 2006;17: 165-172.

Ogunlesi T, Ogundeyi M, Olowu A. Pattern of childhood epilepsy in Shagamu, Nigeria. The Indian Journal of Paediatrics. 2009; 76:385-389.

Bjornaes H, Stabell K, Henriksen O, Loyning Y. The effects of refractory epilepsy on intellectual functioning in children and adults. A longitudinal study. Seizure. 2001;10: 250-259.

Hersha GT, Rajesh Raman, Ravi MD, TSS Rao. A study to assess the magnitude of Depression in Children and Adolescents with epilepsy. International Journal of Clinical Psychiatry. 2018;6(N03):49-51.

Hankin BL. Future Directions in Vulnerability to Depression Among Youths; Integrating risk factors and processes Across Multiple levels of Analyis. J. Clin. Child Adolesc. Psychol. 2012;118:189.

Jemel Seid and Kalayu Mebrahtu. Prevalence and associated factors of depression among people with epilepsy in Ethiopia: A cross sectional study. The symptom Journal of Neurology, Psychiatry and Neuro-Surgery. 2022:58:105.

Marco Mula, Josemir W, Sander. Negative effects of Anti- Epileptic Drugs on mood in patients with epilepsy. Uly. 2007;30:505-567.

Kanner A, Balabanov A. Depression in epilepsy; How closely related are these two disorders? Neurology. 2002;58:7- 29.

Andres K, Susen P. depression in epilepsy; A common but unrecognised comorbidity malady. Chicago, Illinois, Department of Neurological Sciences, Rush Medical College. 2001;(1): 37-51.

Fenwick P. The relationship between mind, brain and seizures. Epilepia .1992;33:1-6.

Harden C. The comorbidity of depression and epilepsy. J. Neurology. 2002;59:48-55.

Herman S, Wilensky A. Increased psychopathology associated with multiple seizure types; facts or artefacts. Epilepsia 1982;23:587-596.