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  3. 2022 - Volume 17 [Issue 4]
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Gamma Transcranial Alternating Current Stimulation Improves Craving and Cognition in Patients with Alcohol Use Disorder: An Open Label Pilot Study

  •   Nikolas Haller
  •   Ulrike Kumpf
  •   Gabi Koller
  •   Frank Padberg
  •   Ulrich Palm

International Neuropsychiatric Disease Journal, Volume 17, Issue 4, Page 37-50
DOI: 10.9734/indj/2022/v17i430211
Published: 16 August 2022

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Abstract


Objective: Alcohol use disorder (AUD) is one of the most common psychiatric disorders worldwide. It often shows a chronic course, and pharmacological treatment is rather ineffective for maintaining abstinence. New non-invasive brain stimulation techniques could help to improve AUD symptoms by rebalancing and synchronizing the disturbed prefrontal brain function and thus reduce craving. This study aims at evaluating the use of gamma transcranial alternating current stimulation to improve clinical und neuropsychological symptoms in patients with AUD.

Methods: In this small open label study, six patients suffering from AUD for several years underwent treatment with prefrontal gamma transcranial alternating current stimulation for 10 min twice daily respectively 20 min once per day for 10 days. Clinical and neuropsychological tests as well as craving were assessed over the course of treatment.

Results: Scores of the Alcohol Craving Questionnaire decreased in all patients and cognitive functions assessed by word fluency and computer-based n-back test improved.

Conclusions: This new non-invasive brain stimulation technique could be of interest in treating craving symptoms and in maintaining abstinence.

Keywords:
  • Brain stimulation
  • alcoholism
  • major depressive disorder
  • cognitive symptoms
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How to Cite

Haller, N., Kumpf, U., Koller, G., Padberg, F., & Palm, U. (2022). Gamma Transcranial Alternating Current Stimulation Improves Craving and Cognition in Patients with Alcohol Use Disorder: An Open Label Pilot Study. International Neuropsychiatric Disease Journal, 17(4), 37–50. https://doi.org/10.9734/indj/2022/v17i430211
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